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Please use this identifier to cite or link to this item: http://elib.bsu.by/handle/123456789/212466
Title: Influence of photon energy on the efficiency of photochemotherapy
Authors: Samtsov, M. P.
Voropay, E. S.
Kaplevsky, K. N.
Melnikau, D. G.
Lyashenko, L. S.
Istomin, Yu. P.
Keywords: ЭБ БГУ::ЕСТЕСТВЕННЫЕ И ТОЧНЫЕ НАУКИ::Физика
Issue Date: 2009
Publisher: Spinger
Citation: Journal of Applied Spectroscopy, Vol. 76, No. 4, 2009
Abstract: It is found that when indotricarbocyanine dye in HeLa cells is exposed to photons with different energies the efficiency of cell damage is wavelength independent provided the photosensitizer absorbs the same number of photons per unit time. In vivo animal experiments with two strains of tumor show that when the wavelength of the irradiating light is increased (668, 740, and 780 nm) and the number of photons absorbed per unit time per unit volume of the tumors is held constant, the damage depth increases by a factor of 1.5 and 3, respectively. The observed changes are related both to differences in the in vivo tissue optical transmission with increasing wavelength and an increased local concentration of oxygen owing to photodissociation of oxyhemoglobin.
URI: http://elib.bsu.by/handle/123456789/212466
Appears in Collections:Кафедра лазерной физики и спектроскопии

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